Abstract
We observed in human and mouse skin that exposure to C. acnes resulted in greatly increased epidermal lipids as indicated by bodily staining and hypothesized that this microbe may regulate keratinocyte lipid metabolism. To test this, human keratinocytes (NHEKs) were exposed to sterile C. acnes supernatant and showed a dose dependent increase in Oil Red O staining (p-value <0.001), and increases of ceramides, cholesterol and free fatty acids detected by differential mobility spectrometry-based shotgun lipidomic analysis.
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