Abstract
The stratum corneum (SC) matrix is composed of free fatty acids, cholesterol and ceramides (CERs), which play a key role in the skin barrier function. The effect of a glycerol/petrolatum-based emollient (G/P-emollient) cream on the lipid profile of the SC in a reconstructed human epithelial (RHE) model was measured. The spatial organization of the cream and the SC intercellular matrix was studied using X-ray diffraction. The inter-bilayer distance in the multi-lamellar lipid structures and lattice type were analyzed using small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS), respectively.
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