#4160 PHASE ANGLE (PA), AGE AND MIS AS MORTALITY PREDICTORS IN PATIENTS WITH ADVANCED CKD

Abstract

Abstract Background and Aims Survival study in Advanced CKD patients according to age, MIS and phase angle Method We studied 225 patients with ACKD, 153 men (68.3%), xage 70.09±12.72 years. We analyze survival at 120 months and how the Phase angle (PA) and MIS scale influence mortality. We chose these parameters, one of body composition (BIA-vector) and the MIS malnutrition-inflammation scale, since they are described as independent predictive factors. Results We defined the cut-off point for PA with the ROC curve, appearing as 3.75 (sensitivity 67% and specificity 55%). With 83 (37.1%) ≤3.75 and 141 (62.9%) greater than 3.75 PA, with significance between men and women p0.001. Analyzing the % of deaths with PA with PC- 3.75 there is a significant difference between groups p0.001 with difference between men and women With a cut-off point of 5 for MIS, we established 162 (72.3%) with ≤5 and 82 (22.7%) with MIS>5. Analyzing the % of deaths according to MIS strata, there is a significant difference p 0.001, Sig difference between men and women p0.021 We define with COR cut-off point age = 70.5 years sens 85% spec 63% 79 patients (64.6%) died in 120 months, 53/152 (65.1%) men and 45/71 (63.4%) women pns. xage deceased 76.39±9.16 vs 66.63±13.14 years p0.001. The survival curves for the 3 variables by Kaplan Meier are significant with the established cut-off points (Fig. 1). In the univariate analysis we found that age (CP-70.5 years) p0.001, and PA (CP-3.75) p0.04 are significant, but not MIS(CP-5). In the Cox analysis we evaluated age, PA and MIS, with age appearing as a priority, followed by PA and finally the statistical MIS Wald 18.73, 3.77 and 2.26 respectively. Conclusion 1-Age, phase angle and MIS are independent mortality risk factors for ACKD patients. 2-In the multivariate model Age and phase angle are predictors of mortality. 3-Independent of age, the phase angle is the best predictor of mortality.