Abstract
diabetes occurred. Surgical interventions for pericardial effusions were necessary in 5 patients. 9 patients intermittently discontinued sirolimus treatment due to side effects or adverse events (4 acute rejections, 3 delayed wound healing, 2 GI-toxicity). Conclusions: De novo CNI-free immunosuppression after heart transplantation is less efficacious in prevention of acute rejection and is associated with a variety of side effects. On the other hand CNI-free immunosuppression is possible and long-term results are favourable for survival, malignancy, renal function, CMV-infections and vasculopathy.
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