Abstract
Atopic dermatitis (AD) is an often severely pruritic chronic inflammatory disease often worsened by psychological stress. Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide, which may cause pruritus. Earlier studies indicate a special pathogenetic role for CGRP in AD. However, somewhat contradictory results regarding CGRP positive nerve fibers in AD skin, have been reported. We have studied skin biopsies from 26 patients with AD. The biopsies were taken from lesional and non-lesional skin, in addition, normal skin biopsies from 10 healthy individuals were investigated for expression of CGRP, using a biotinylated–streptavidine technique and fluorescence microscopy.
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