Abstract
Methods for catalytic enantioselective Michael reactions, aldol reactions, and Mannich(-type) reactions via in situ catalytic generation of metal enolate species are described in this chapter. For the direct Michael reactions, examples using 1,3-dicarbonyl compounds, nitroalkanes, glycinate Schiff bases, hydroxyketones, and vinylogous donors are introduced. For the direct aldol reaction, reactions with α-isocyanate esters and their derivatives, ketones, and carboxylic acid derivatives as donors are discussed. Finally, direct Mannich-type reactions with 1,2-dicarbonyl compounds, hydroxyketones, 1,3-dicarbonyl, and related compounds, glycinate Schiff bases, ester surrogates, and vinylogous donors are described. Synthetically useful, highly enantioselective catalytic methods are mainly selected and explained in detail.
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