412-P: Increased Peripheral Neutrophil Count Is Closely Associated with the Incidence and Progression of Chronic Kidney Disease in Older Type 2 Diabetic Patients

Abstract

Preventing and managing chronic kidney disease (CKD) is the primary task of the overall management of T2DM. An increasing number of studies has indicated that low-grade chronic inflammation plays a crucial role in the pathophysiology of CKD. A total of 3345 subjects were recruited in this study of whom 1257 derived from one centre and served as case-controls and 2088 with T2DM derived from two other centres and were followed up annually for 4 years and entered into a retrospective cohort study. In the case-control study, neutrophil count performed best as an independent risk factor for CKD even after 1:1 case-control matching for age, gender, and history of high blood pressure (HBP). Spline regression revealed a significant linear association between CKD incidence and continuous neutrophil count in excess of 3.6 × 109/L. In the cohort study, subjects were grouped based on tertile of neutrophil count and neutrophil-to-lymphocyte ratio (NLR), respectively. COX regression analysis showed that only neutrophil count demonstrated an increased HR for estimated glomerular filtration rate (eGFR) reduction greater than 30% (the highest group vs. the lowest group, 1.604 (1.029 - 2.501), P < 0.05) after fully adjusting for potential confounders. The cumulative incidence of CKD in T2DM patients gradually increased with increasing neutrophil count. This study suggested that neutrophil count is associated with the incidence and progression of CKD in T2DM patients. Disclosure R. Zhang: None. Funding Medical Key Faculty Foundation of Shanghai (ZK2019B15)