411 Keratinocytes drive a specific inflammatory gene signature in pityriasis rubra pilaris

Abstract

Pityriasis rubra pilaris (PRP) represents a group of rare inflammatory skin disorders. Diagnosis is often challenging, its treatment is mainly empirical and suffers from the lack of controlled trials. PRP shares overlapping clinical and histological features with psoriasis, suggesting a common underlying pathophysiology. Based on this resemblance, a role of the IL23–TH17-axis in PRP was proposed, and several cases of successful treatment of PRP with psoriasis biologics were reported. However, efficacy remains variable and these therapeutic options lack a valid immunopathological rationale.