Abstract
The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hydroxy groups giving an intramolecular hydrogen bond to a ketone O-atom acceptor. The molecules also form intermolecular hydroxy–ketone O—H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids.
Highlights
Crystal dataR factor = 0.093; wR factor = 0.331; data-to-parameter ratio = 13.6
The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from
The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry
Summary
R factor = 0.093; wR factor = 0.331; data-to-parameter ratio = 13.6. The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hydroxy groups giving an intramolecular hydrogen bond to a ketone Oatom acceptor. The molecules form intermolecular hydroxy–ketone O—H O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids
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