#409 Correlation between ha factor concentration and urinary syndrome in patients with chronic glomerulonephritis when using rivaroxaban

Abstract

Abstract Background and Aims Considering the pathogenetic role of factor X of the coagulation system in the formation and progression of chronic glomerulonephritis (CGN), as well as the mechanism of action of rivaroxaban, this study examined the concentration of coagulation factor X in peripheral blood. Aim of our study to reveal the pathogenetic relationship between the concentration of Xa factor and the severity of urinary syndrome in patients with CGN on the background of basic therapy with the inclusion of rivaroxaban. Method 108 CGN patients, on the background of 3-month baseline therapy with inclusion of rivaroxaban (AC+ group, 55 patients) and without anticoagulant (AC- group, 53 patients). Initially and after 3 months of the study the concentration of coagulation factor Xa in peripheral blood was studied. Results In CGN patients the concentration of Xa factor was significantly higher than in CG (122.17 ± 2.23% vs. 104.28 ± 6.54% in CG, p < 0.05). On the background of 3-month therapy including antiaggregant, corticosteroid hormone and cytostatic, the concentration of Xa factor decreased by 18.82 ± 0.64% (p < 0.001 reliability of difference with initial data). The use of rivaroxaban, as expected, was associated with a more significant decrease in Xa factor level—by 38.76 ± 1.40% (p < 0.001 significance of difference with baseline data; significance of difference in relative dynamics of Xa factor concentration between groups depending on anticoagulant use, p < 0.001). Correlation analysis revealed a significant positive strong correlation between the initial concentration of Xa factor in peripheral blood of CGN patients and the severity of hematuria (r = 0.83, p < 0.01) and a positive weak correlation between the concentration of Xa factor and cylindruria as a manifestation of proteinuria (r = 0.30, p < 0.01), as well as a positive weak correlation between the concentration of Xa factor and cylindruria at the end of the 3rd month of observation (r = 0.33, p < 0.01). There was also found a significant negative weak correlation between the initial concentration of Xa factor and the relative dynamics of hematuria (r = −0.48, p < 0.01) and cylindruria (r = −0.33, p < 0.01). Conclusion The study confirmed the pathogenetic relationship between the concentration of Xa factor and the severity of urinary syndrome in CGN patients. It was also found that initially high concentration of Xa factor is associated with less positive dynamics of urinary syndrome parameters.