405 Understanding the biologic regulation and impact of Long Interspersed Nuclear Element (LINE-1) retrotransposon reactivation in keratinocytes undergoing phototherapy treatments.

M Lambert,I Litvinov

doi:10.1016/j.jid.2022.09.418

405 Understanding the biologic regulation and impact of Long Interspersed Nuclear Element (LINE-1) retrotransposon reactivation in keratinocytes undergoing phototherapy treatments.

M Lambert, I Litvinov

Open Access

https://doi.org/10.1016/j.jid.2022.09.418

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Journal: The Journal of investigative dermatology	Publication Date: Nov 18, 2022
License type: publisher-specific-oa

Affiliation: McGill University

#Broadband Ultraviolet B #Narrow Band Ultraviolet B + Show 8 more

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Abstract

Narrow band ultraviolet B (NB-UVB) and Broad band ultraviolet B (BB-UVB) are commonly used for the treatment of Atopic Dermatitis (AD) among others, and has been shown by us and others to trigger LINE-1 reactivation in human keratinocytes. LINE-1 constitutes ∼17% of human genome, has played important evolutionary role, and its reactivation may result in deleterious effects leading to DNA damage, cellular senescence and photoaging. We established a model of NB-UVB or BB-UVB irradiation on keratinocytes, and showed that these induced an increase in LINE-1 expression.

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