Abstract
CMV infection remains a serious opportunistic infection in lung transplant recipients (LTRs), with donor+/recipient- (D+/R-) LTRs particularly at increased risk. We have previously shown that CMV-specific CD8+ T cell responses are immunodominant during acute primary CMV infection, with lung allograft CD8+ T cell effector responses predominant over the blood. The relationship between CMV-specific compartmental phenotype and immunologic memory in LTRs during chronic infection and durable viral control remain largely undefined. Studies of CMV-specific compartmental immunity are critical to establish whether viral control is achievable in this population without long-term antiviral therapy.
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