Abstract
The tumor microenvironment (TME) is comprised of interacting cancer and stromal cells. The TME plays a major role in tumor behavior. This chapter reviews the development of three different colors of transgenic mice ubiquitously expressing either red fluorescent protein, green fluorescent protein, or cyan fluorescent protein for use to color the tumor stroma. This chapter demonstrates how cancer cells, expressing various colors of fluorescent proteins, implanted in the colored nude mice, enable the real-time imaging of the cancer cell–stromal cell interaction in real time in live mice. This technology described here demonstrated that stromal cells are necessary for cancer cells to metastasize.
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