Abstract
Critical for the maintenance of epidermal stability and function are attachments between intermediate filaments (IF) and intercellular junctions called desmosomes. The desmosomal cytoplasmic plaque protein desmoplakin (DP) is essential for anchoring IF to the junction. DP-IF interactions are regulated by a phospho-regulatory motif within the DP C-terminus. Previously we showed that hypo-phosphorylated DP increased DP-IF interaction strength, impairing desmosome formation due to DP retention on IF, but generated stronger, more stable desmosomes in mature cell sheets.
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