400 308-nm excimer lamp ameliorates MC-903 induced atopic dermatitis with a reduction of thymic stromal lymphopoietin mRNA levels

Abstract

Purpose Narrow band-ultraviolet B (NB-UVB) is efficacious for atopic dermatitis (AD). However, its detailed mechanism remains to be elucidated. The purpose of this study is to explore an in vivo-effect of NB-UVB on AD, utilizing MC903-induced AD model mice. Method To induce AD-like dermatitis, MC903, a vitamin D3 analogue, was applied on the shaved dorsal skin of C57BL/6 mice once a day for twelve days. Mice were irradiated with a 308-nm excimer lamp at 100 mJ/cm2 once every other day from days 0 to 10.