Abstract
It has been reported that the 24-hour integrated concentraticn of GH is higher in F than in M. These differences should be secondary to different GH production rates provided that metabolic clearances rates (MCR) were similar in the two sexes. To clarify this point, GH HL was studied in 5 F and 4 M. Serum estradiol (nmol/L) was 329±103 and 31.4±29.3 and serum testosterone (nmol/L) 1.63±1.21 and 13.5±2.29 in F and M, respectively. No food was allowed since the previous night. GH secretion was stimulated with a single IV bolus of GH-RH (3 ug/Kg) followed at 30 min of a single IV bolus of 250 ug somastotatin (S). After drawing 3 basal samples every 15 min. Sampling was continued every 5 min for 90 min after GH-RH. GH HL was calculated after S injection when a decrease was found in at least 3 consecutive GH values. Basal GH was not significantly different in the two groups (M:1.15±0.33, F:3.97±4.91 ng/ml) but the maximal increment was lower in M than in F (19.2±8.64 an 43.8±18.6, p < 0.05) HL was calculated assuming a monoexponential decay. HL and MCR were not statistically different in M and F (HL:15.2±2.35 and 13.2±2.74 min; MCR:4.77±0.45 and 5.26±0.23 ml/min. Kg, respectively). It is concluded that there are no differences in GH release rate between M and F.
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