Abstract

Studies using human monoclonal antibodies have been instrumental in elucidating basic concepts in immunology and basic disease mechanisms in a variety of human disorders. Many human monoclonal antibodies that recognize known antigens specifically bind to carbohydrates. In particular, many of these antibodies recognize blood-group antigens. The serum of a patient presenting with chronic cold hemagglutinin disease contains an antibody recognizing an oligosaccharide antigen on red blood cells. In patients with plasma cell dyscrasia and peripheral neuropathy, the monoclonal antibody often binds to antigenic determinants on peripheral nerve myelin. This chapter lists some carbohydrate-specific human monoclonal antibodies in a tabular form.

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