Abstract
This chapter discusses an approach to control filariasis by the use of a new class of pharmacological agents, benzimidazoles. There are six species of human filariasis for which it is desirable to develop antifilarial agents: Wuchereria bancrofti , Brugia malayi , and Onchocerca volvulus are major human pathogens, responsible for practically all filaria-related deaths. Mansonella ozzardi , Dipetalonema perstans , and Loa Loa are less prevalent species. Benzimidazoles have been identified as antifilarial agents based on an extensive series of studies in jirds (a kind of gerbil) and cats. The mechanism of the action of benzimidazoles has been extensively studied in many laboratories, and, in general, three possible modes of action have been suggested for these drugs. It has been demonstrated by numerous workers that the majority of benzimidazoles inhibit the microtubulin of tegumental or intestinal cells of nematodes or cestodes through the degeneration of these cells. This mechanism is now well accepted as the mode of action for benzimidazole derivatives.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
