4-Iodophenylboronic Acid Stabilized Gold Cluster as a New Fluorescent Chemosensor for Saccharides Based on Excimer Emission Quenching.

Abstract

4-iodophenylboronic acid (IPBA) ligated luminescent gold cluster was synthesized by mixing an aqueous solution of IBPA and polyvinylpyrrolidone stabilized gold cluster (Au:PVP) in water at room temperature through chemisorption of iodine on gold nano surface. Transmission Electron microscopy (TEM) and matrix assisted laser desorption ionization (MALDI) analysis revealed that the size of these Au-clusters (1.4±0.2nm) remain unchanged without any noticeable aggregation during synthesis. Owing to the formation of excimer between aryl moieties grafted over Au surface, the cluster exhibit strong emission peak at 335nm. This luminescent gold cluster is used for sensing different saccharides in water at physiological pH through quenching of excimer emission peak. This strong excimer emission is significantly quenched in presence of saccharides through interaction with boronic acid moieties. The selectivity for different saccharides follows the order: fructose > galactose > maltose > glucose ~ ribose > sorbitol with hight affinity for fructose (KSV = 1.54 × 104M-1) with Limit of Detection (LOD) of 100μM.