Abstract
With the aim of deducing a structure-biological dependence we have carried out the synthesis of quinoline-3-carboxylic acid N-R-amides with a p-methoxyphenyl substituent in the amide part of the molecule. The effects of the compounds prepared on the excretory function of the kidney are discussed. Using a system of simplex descriptors and the method of tree type classification a QSAR model has been constructed which is suitable for prediction of the diuretic activity of novel quinolinecarboxylic acid N-R-amides.
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