4-Dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1 H-pyrazol-4-yl)butan-1-ols: synthesis and evaluation of analgesic, anti-inflammatory and platelet anti-aggregating activities

Abstract

A number of 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1 H-pyrazol-4-yl)butan-1-ols 2a– n were synthesized and tested in vivo for anti-inflammatory and analgesic activities and in vitro for platelet anti-aggregating activity. Dimethylaminoderivatives 2b, e, g showed good analgesic activity; almost all of them had strong platelet anti-aggregating properties at a final concentration of 1×10 −3 M; pyrazoles 2c, d, f– h showed weak anti-inflammatory activity.