4 cases of intraspinal primitive neuroectodermal tumor

Abstract

Objective To investigate the diagnosis, patterns, pathology and treatment of primary intraspinal primitive neuroectodermal tumor (PNET). Methods The clinical materials of 4 intraspinal PNET, such as image data, histopathoiogy features, methods of treatment, were analyzed retrospectively. Results All cases were treated by surgery, 3 cases underwent total resection and 1 cases subtotal resection. 2 central primitive neuroectodermal tumors and 2 peripheral primitive neuroectodermal tumors were revealed by histopathological examination and immunohistochemical staining. Among the 4 cases who had been followed up, 3 underwent radiotherapy and chemotherapy, 1 did not receive any adjuvant therapy due to socioeconomic issues. Conclusions The age of intraspinal PNET is much older than the average age of manifestation for intracranial PNET. The history of intraspinal PNET is short. It is important that chemotherapy plans for cPNET are different from those for pPNET; Expression of CD99 offers an easy way of making a differential diagnosis between the central and peripheral PNET. Key words: Spinal canal; Primitive neuroectadermal tumor; Neurosugical procedures