Abstract
AbstractThermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1‐methyl‐4‐aryl‐5‐trifluoromethylimidazoles 2 in good yields. In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1‐methyl‐4‐trifluoromethyl‐5‐aryl‐imidazoles 5 as major products. These reactions could be extended to the syntheses of related several 1,4,5‐trisubstituted imidazoles.
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