Abstract
Purpose: Epigenetic changes, including DNA methylation, regulate cellular homeostasis. We previously showed that DNA methyltransferase 3B (DNMT3B) expression is reduced in murine and human osteoarthritic (OA) articular chondrocytes (ACs); and that DNMT3B loss-of-function (LOF) leads to OA in mice. An unbiased screen of genes regulated by DNMT3B showed that 4-aminobutyrate aminotransferase (Abat) is increased with DNMT3B LOF. Moreover, upregulation of Abat expression in articular chondrocytes was observed in human OA and injury induced murine OA cartilage.
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