4:21 PMAbstract No. 177 - Trends in renal function following percutaneous cryoablation of renal mass in patients with and without renal compromise

Abstract

Cryoablation is a widely accepted intervention for treating small renal tumors however the post procedure renal function can potentially deteriorate. We aim to study the post cryoablation trends of renal function with serum creatinine in patient with or without prior renal compromise. An IRB approved retrospective review of percutaneous cryoablation on renal tumors was performed between April 2009 and August 2015. Medical records were reviewed for prior renal surgeries, renal ablation and known chronic kidney disease (CKD). Post ablation renal function was compared between two groups: patients without prior renal compromise or renal intervention (Simple) and patient with prior renal compromise (CKD) and/or renal intervention (Complex). CKD was defined with creatinine ≥ 2mg/dl. Follow up time was categorized into time 0 (the most recent pre-ablation creatinine); time 1 (≤30 days), time 2 (31-90 days), time 3 (91-180 days), time 4 (181-300 days) and time 5 (>301 days). Baseline and post ablation follow up global renal function was assessed with serum creatinine. The cohort consisted of 39 patients with 77% male and average age of 68 years. Patients without prior renal compromise or renal intervention n= 15 (38.46%) and patient with prior renal compromise including CKD and/or renal intervention n= 24 (61.54%) had mean tumor size of 3.0 cm (SD 1.1) and 2.4 cm (SD 1.2) respectively. Mean follow up period was 12 months (range 1-53). There was slight interval increase in post cryoablation creatinine in the first month and the annual follow up, more so in the complex group as compared to the simple group (0.38 vs. 0.11 mg/dl) and (0.49 vs. 0.25 mg/dl) however no mean creatinine value was ≥ 2mg/dl. Cryoablation of renal tumors provides good preservation of renal function in patients with or without prior renal compromise and could be considered as an option to other nephron sparing procedures/ surgeries.