Abstract
Biomarker, neuroimaging, and genetic findings implicate the serotonin (5-HT) system in autism spectrum disorder (ASD). Several groups have investigated clinical correlates of 5-HT in ASD, with minimal and inconsistent findings across studies. The maternal 5-HT system influences embryonic forebrain 5-HT levels and neurodevelopment in mice. Given emerging evidence pointing to maternal genotype as a contributor to offspring risk of neurodevelopmental abnormalities, we evaluated whether the maternal 5-HT system is associated with phenotype in children with ASD.
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More From: Journal of the American Academy of Child & Adolescent Psychiatry
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