4-(1 H-Indazol-5-yl)-6-phenylpyrimidin-2(1 H)-one analogs as potent CDC7 inhibitors

Cynthia M Shafer,Mika Lindvall,Cornelia Bellamacina,Thomas G Gesner,Asha Yabannavar,Weiping Jia,Song Lin,Annette Walter

doi:10.1016/j.bmcl.2008.07.061

4-(1 H-Indazol-5-yl)-6-phenylpyrimidin-2(1 H)-one analogs as potent CDC7 inhibitors

Cynthia M Shafer, Mika Lindvall + Show 6 more

https://doi.org/10.1016/j.bmcl.2008.07.061

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Journal: Bioorganic & Medicinal Chemistry Letters	Publication Date: Jul 17, 2008
Citations: 30

Affiliation: Novartis (United States)

#Medicinal Chemistry Techniques #Molecular Modeling Techniques + Show 8 more

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Abstract

A series of 4-(4-hydroxyphenyl)-6-phenylpyrimidin-2(1 H)-ones were identified by HTS as inhibitors of CDC7. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus on removing potential metabolic liabilities and improving cellular potency.

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