Abstract
The history, biological rationale and present status of clinical application of hyperthermia in cancer therapy were reviewed. Clinical hyperthermia is divided into whole-body and local hyperthermia. The former is applied to patients with far advanced disseminated malignancy and some encouraging results have been obtained. Clinical benefits of local hyperthermia combined with radiotherapy have been widely demonstrated for superficial tumors. With the recent development of deep-heating equipment, local hyperthermia for deep-seated tumors is being intensively investigated.
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