Abstract
The autoradiographic localization of [ 3H]prazosin (α 1-adrenoceptor ligand) binding sites was determined in cat spinal cord sections. High levels of [ 3H]prazosin binding were found in the intermediolateral cell column (IML) at thoracic and lumbar levels. The iontophoresis of theα 1-adrenoceptor agonist methoxamine onto sympathetic preganglionic neurones (SPNs) in anaesthetized cats and rats caused excitation of 8 cat SPNs and 13 rat SPNs. These results suggest an excitatory role for some of the catecholaminergic of the IML.
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