Abstract
We examined the degree of binding of the calcium antagonist, [ 3Hnitrendipine ([ 3HNDP), in the prefrontal cortex, caudate nucleus, putamen, pallidum and substantia nigra obtained at autopsy from patients with Parkinson's disease. The specific bindings of [ 3HNDP were significantly reduced in the caudate nucleus, putamen and substantia nigra, as compared to the relevant controls. Scatchard analyses revealed that these reductions resulted from decreased in the apparent maximum number of binding sites (B max). The affinity constants ( K d ) remained unchanged. Thus, it is highly likely that calcium channel antagonist binding sites on nigral dopamine (DA) neurons may be lost in the degenerative process of Parkinson's disease.
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