Abstract
Specific dopamine receptors were studied in freshly dissected, unhomogenized rabbit carotid bodies incubated in [ 3H]spiroperidol. Total binding and non-specific binding were determined in the absence and presence of 0.2 μM (+)-butaclamol, respectively. Specific binding in normal carotid bodies incubated at near saturating concentrations (0.38 nM) was 1.63 ± 0.58 pmol/g of tissue. Chronic section of the carotid sinus nerve (14 days) resulted in a 64% reduction ( P < 0.05) in specific binding. We conclude that the majority of specific dopaminergic receptors are located on carotid sinus nerve afferent terminals.
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