Abstract
1. 1. [ 3H]serotonin binds to two classes of sites in a crude membrane preparation of Drosophila melanogaster heads, with apparent K d values of 1.4 and 130nM, and a concentration of 0.2 and 1.5 pmol/mg protein, respectively. 2. 2. High salt concentration and a guanyl nucleotide decrease the number of the high-affinity binding sites. 3. 3. Low concentrations of ergot alkaloids, various tryptamine derivatives, neuroleptic drugs, but not of phentholamine, propranolol and dopamine, displace [ 3H]serotonin from its high affinity sites. 4. 4. The relevance of the [ 3H]serotonin-binding sites to serotonin receptors in Drosophila is discussed.
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