Abstract
Specific [ 3H]nitrendipine binding which was shown to be calcium- and calmodulin-dependent was found to be significantly reduced in the temporal cortex in Alzheimer's disease compared to age-matched controls. Scatchard analysis revealed that this reduction was due to a loss in the number of cortical [ 3H]nitrendipine binding sites rather than a change in the affinity of the binding site in the Alzheimer patients. The reduction in cortical [ 3H]nitrendipine-specific binding was most marked in those Alzheimer's disease cases where the duration of the dementing illness was longer than two years. In contrast, no reduction in cortical [ 3H]nitrendipine binding was found in Huntington's disease. There was no significant correlation found between age (38–89 years) and [ 3H]nitrendipine binding in control cases, or between mean overall plaque counts and [ 3H]nitrendipine binding in the Alzheimer's disease cases. There was a significant correlation found between age (46–88 years) and [ 3H]nitrendipine binding in the Alzheimer's disease cases where the duration of the dementing illness was greater than two years.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
