Abstract
[ 3H]Nisoxetine binds with high affinity (K d = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [ 3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at its K d concentration. Pretreatment with the neurotoxin DSP-4 resulted in 95% decrease in binding. [ 3H]Nisoxetine exhibits superior properties to radioligands previously used and appears to be the radioligand of choice for studies involving uptake sites for norepinephrine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
