Abstract
The specific binding of [ 3H]hemicholinium-3 ([ 3H]HCh-3) and high-affinity [ 3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine. The specific binding of [ 3H]HCh-3 in cortex and hippocampus from rats with status epilepticus increased to 2- to 3-fold of control while the striatal [ 3H]HCh-3 binding increased minimally. Scatchard analyses revealed that the observed changes resulted from an increase in B max of [ 3H]HCh-3 binding. High-affinity [ 3H]choline uptake remained unchanged. These results further implicate phospholipase A 2 in the regulation of [ 3H]HCh-3 binding sites.
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