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Abstract
Quantitative autoradiography was used to characterize the regional binding parameters of [ 3H]cyclohexyladenosine (CHA) and the regional inhibition of specific [ 3H]CHA binding observed with a series of adenosine agonists and antagonists. Under the conditions described [ 3H]CHA binding was best fit by a single, high affinity site model in all areas examined. No major regional differences were observed in the inhibition of [ 3H]CHA binding by the adenosine and xanthine analogs examined. Overall, the rank order of activity throughout all regions was CPA> R-PIA>NECA⪢PACPX⩾2-CADO⩾ S-PIA⪢DPX.
Published Version
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