Abstract
We examined the specific binding of [ 3H]CL 218,872, a novel triazolopyridazine to benzodiazepine receptors in the rat cerebral cortex. Two binding sites with K D values of about 10–30 nM and 200–600 nM were demonstrated. A number of benzodiazepine anxiolytics inhibited [ 3H]CL 218,872 binding in a manner which correlates with the potency of these drugs for inhibiting [ 3H]benzodiazepine binding. Our initial studies show that [ 3H]CL 218,872 can label the benzodiazepine receptors and may prove to be a useful probe for studying benzodiazepine heterogeneity and regulation.
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