3D-Zellkultur zur Identifizierung von Zielmolekülen für die Krebstherapie

Abstract

Malignant tumors often show radio- and chemoresistance phenotypes resulting from genetic mutations and epigenetic regulation. As molecular examinations for therapy optimization in patients and animal models are often challenging or infeasible, matrix-based 3-dimensional (3D) cell culture models have been developed as powerful tools in translational research to unravel the mechanisms of cancer cell survival, proliferation and metastasis as well as to identify potential cancer targets.