3D Rotation‐Trackable and Differentiable Micromachines with Dimer‐Type Structures for Dynamic Bioanalysis

Gungun Lin,Denys Makarov,Yinghui Chen,Guan Huang,Jun Lin,Yuan Liu,Zewei Quan,Dayong Jin

doi:10.1002/aisy.202000205

Abstract

Utilizing the magnetic interactions between microparticle building blocks allows creating long‐range ordered structures and constructing smart multifunctional systems at different scales. The elaborate control over the inter‐particle magnetic coupling interaction is entailed to unlock new magnetoactuation functionalities. Herein, dimer‐type microstructures consisting of a pair of magnetic emulsions with tailorable dimension and magnetic coupling strength are fabricated using a microfluidic emulsion‐templated assembly approach. The magnetite nanoparticles dispersed in vinylbenzene monomers are partitioned into a pair of emulsions with conserved volume, which are wrapped by an aqueous hydrogel shell and finally polymerized to form discrete structures. Tunable synchronous–asynchronous rotation over 60 dB is unlocked in magnetic dimers, which is shown to be dependent on the magnetic moments induced. This leads to a new class of magnetic actuators for the parallelized assay of distinctive virus DNAs and the dynamic optical evaluation of 3D cell cultures. The work suggests a new perspective to design smart multifunctional microstructures and devices by exploring their natural variance in magnetic coupling.

Highlights

Discrete magnetically actuated assembly structures[12,13,14,15] are preferred for nonparticles dispersed in vinylbenzene monomers are partitioned into a pair of tethered and contactless operations, flexible emulsions with conserved volume, which are wrapped by an aqueous hydrogel shell and polymerized to form discrete structures
Tunable synchronous– asynchronous rotation over 60 dB is unlocked in magnetic dimers, which is shown to be dependent on the magnetic moments induced
To tailor the interaction between the magnetic building blocks, we put forth a compartmentalization-assembly strategy (Figure 1) to synthesize dimer-type structures consisting of two magnetic particle compartments

Summary

Results and Discussion

This result further confirms that the major magnetic driving force comes from the minor permanent moment for the class of single-compartment structures. Fitting the above-mentioned data to the relationship described in Equation (5) yields the magnetic susceptibility of the structures (%9.1) that is consistent with the provided value (18.6) of the ferrofluids (EMG 900) with a volume fraction of 50% This result indicates that tuning the synchronous-to-asynchronous transition states of the unconventional class of dual-compartment microstructures relies on induced magnetic moments, which is in stark contrast with that of single-compartment ones. The unlocked tunability in the characteristic critical rotation frequency, found in dual-compartment microstructures, can be spanning over 60 dB owing to the enhanced magnetic field-structure interactions (Supplementary Section 1, Supporting Information)

Multiaxial Positioning of 3D Multicellular Constructs for Evaluation

Parallelized Analysis of Distinctive Biomolecular Analytes

Conclusion

Experimental Section

Conflict of Interest