Abstract
DNA replication is a vital process in all organisms and understanding the fundamental biochemical interactions that drive replication is essential. Single‐stranded DNA‐binding (SSB) proteins form an important component of the replication machinery that facilitates the transfer of RNA primers from the enzyme primase to the replicative polymerase. This activity occurs throughout lagging‐strand DNA replication. The crystal structure of the E. coli χψ subunit of the DNA polymerase III holoenzyme bound to its interaction site on SSB has been determined. The Madison West High School Students Modeling a Research Topic (SMART) Team, in collaboration with the Milwaukee School of Engineering, has modeled this interaction using 3D Rapid Prototyping Technology to gain insights into the physical interactions that drive DNA replication. The SMART team program allows students to experience the scientific process beyond the textbook by investigating the experimental methodology of structural biology and takes students out of the classroom and into the laboratory. Supported by grants from the Howard Hughes Medical Institute and NIH‐NCRR‐SEPA.
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