3D RADIOTHERAPY IN THE PAROTID GLAND AND ITS DOSIMETRIC RELATIONSHIP WITH SALIVARY FLOW AND QUALITY OF LIFE

Abstract

<h3>Objectives</h3> To evaluate the dosimetric relationship between 3D radiotherapy and changes in salivary flow, xerostomia, and quality of life in patients with head and neck cancer according to the volume of the irradiated parotid gland. <h3>Study Design</h3> Twenty-three patients with cancer in the head and neck area and in need of 3D radiotherapy were followed up during radiotherapy treatment, and the parotid gland (PG) design was also performed in radiotherapy planning. Questionnaires were carried out to determine xerostomia and quality of life, and salivary flow was determined through calculations involving the collection and weighing of saliva. The numerical variables were represented by measures of central tendency and measures of dispersion. <h3>Results</h3> When associating salivary flow, the xerostomia questionnaire, and quality of life, a statistically significant difference was found (<i>P</i> < .001). However, no relationship was found between dosimetry data, xerostomia, and hyposalivation. <h3>Conclusions</h3> Patients undergoing 3D radiotherapy for malignant neoplasms in the head and neck region had decreased salivary flow, increased complaints of dry mouth, and decreased quality of life; however, it was not possible to establish a statistically significant correlation between these findings and the volumes of irradiated parotids.