3D quantıtatıve structure actıvıty relatıonshıp of tetrahydroımıdazo [1,2-a] pyrımıdıne as antımıcrobıal agents

Abstract

A series 24 tetrahydroimidazo[1,2-a] pyrimidine derivatives were subjected to 3D quantitative structure activity relationship for antimicrobial activity. Partial least square methodology was utilized for the development of QSAR models. Six different QSAR models have been generated for antimicrobial efficiency of tetrahydroimidazo[1,2-a] pyrimidine derivatives against three human pathogens. QSAR models revealed positive influence of steric and electronic parameters on antimicrobial potential - of tetrahydroimidazo[1,2-a] pyrimidine derivatives.