Abstract
The challenges in bone tumor therapy are how to repair the large bone defects induced by surgery and kill all possible residual tumor cells. Compared to cancellous bone defect regeneration, cortical bone defect regeneration has a higher demand for bone substitute materials. To the best of our knowledge, there are currently few bifunctional biomaterials with an ultra-high strength for both tumor therapy and cortical bone regeneration. Here, we designed Fe-CaSiO3 composite scaffolds (30CS) via 3D printing technique. First, the 30CS composite scaffolds possessed a high compressive strength that provided sufficient mechanical support in bone cortical defects; second, synergistic photothermal and ROS therapies achieved an enhanced tumor therapeutic effect in vitro and in vivo. Finally, the presence of CaSiO3 in the composite scaffolds improved the degradation performance, stimulated the proliferation and differentiation of rBMSCs, and further promoted bone formation in vivo. Such 30CS scaffolds with a high compressive strength can function as versatile and efficient biomaterials for the future regeneration of cortical bone defects and the treatment of bone cancer.
Highlights
The treatment of bone cancer has received considerable attention from scientists and clinicians[1,2]
Compared to cancellous bone defect regeneration, cortical bone defect regeneration has a higher demand for bone substitute materials, which should have satisfactory biological activities and possess a high compressive strength to match that of cortical bone
Synthesis and characterization of the 30CS scaffolds In our study, the Fe-CaSiO3 composite powder was obtained by ball-milling, and 40CS, 30CS, 20CS, 10CS (CaSiO3 mass percent: 40, 30, 20, and 10%, respectively) and pure Fe scaffolds were fabricated by a 3D printing method
Summary
The treatment of bone cancer has received considerable attention from scientists and clinicians[1,2]. The composite scaffolds with a high compressive strength exhibited the synergistic effects of photothermal and ROS tumor therapies and the ability to promote bone regeneration.
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