Abstract
The modification of 3D printed porous titanium (Ti), especially for the internal pore structure, is critical and has received more attention to promoting its osteogenesis for clinical use. Ultra-violet (UV) responsive chitosan (CSMA), as an injectable filling material, was firstly incorporated into porous Ti, and then CSMA was in-situ mineralized by carbon oxide (CO2) diffusion (CSMA/CaCO3). Their physical-chemical and biological properties were investigated in vitro. CaCO3 crystals within CSMA hydrogels were successfully deposited into pores of porous Ti, which exhibited favorable biocompatibility. Ti implants filled with CSMA/CaCO3 promoted adhesion and proliferation of bone mesenchymal stem cells (BMSCs). Moreover, Ti implant filled CSMA/CaCO3 hydrogels could increase alkaline phosphatase (ALP) activities, up-regulate osteopontin (OPN) and osteocalcin (OCN) expression levels, and enhance extracellular mineralization. 3D printed porous Ti filled with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs, and have great potential for the modification of porous Ti implants in bone tissue engineering.
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