Abstract
Over the last four decades, magnetic resonance imaging has become the gold standard imaging technique in many medical diagnoses for brain, cardiac, and liver disease. However, due to low critical mass and great scientific challenges, instrumentation dedicated to preclinical MRI imaging has lagged behind instrumentation for clinical applications. The aim of this paper is to demonstrate that a set of new technologies such as the 3D Molded Interconnect Devices technology preferably named below as 3D Plastronics, 3D Printing, and Microfluidics may be considered to provide a completely new way for designing preclinical MRI setups, i.e., the 3D prototyping and manufacturing of the MR coil, the sample holder, and the peripherals, all together. The fabricated MRI setup can be used both for MRI of small biological samples and for in vivo imaging of a mouse brain. This work is the first step toward the full 3D manufacturing of tailor-mad multifunctional MRI probes.
Highlights
Over the last four decades, magnetic resonance imaging (MRI) has become the gold standard imaging technique in many medical diagnoses related to brain [1], cardiac [2], and liver disease [3]
Taking into account all these requirements, the aim of this paper is to demonstrate that a set of new technologies such as the 3D Molded Interconnect Devices technology (3D MID)
The whole full 3D printed MRI setup is presented on Figure 6 with, on the left hand side, a zoom on the MR coil integrated within the packaging chamber and, on the right hand side, the whole MRI setup with the mouse positioned for MRexamination
Summary
Over the last four decades, magnetic resonance imaging (MRI) has become the gold standard imaging technique in many medical diagnoses related to brain [1], cardiac [2], and liver disease [3]. There has been growing interest in multiparametric acquisitions in order to assess the complexity of heterogeneous biological tissue changes involved in target diseases. In this context, the fast and tremendous advances in MRI have been possible thanks to huge technological developments leading to a substantial increase of the signal to noise ratio (SNR) obtained either by an increase of the static magnetic field intensity [4] or by the development of new radiofrequency (RF) coils [5]. Working with preclinical MRI implies working with smaller coils operating at higher frequency than clinical coils This leads to reduced SNR due to higher electric and sample losses, and tunability becomes more of an issue. The main goal of this work is to provide a new set of low cost and adaptable manufacturing tools in order to facilitate the development of a dedicated preclinical MRI setup
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