Abstract
The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method—the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.
Highlights
Nowadays, Mueller-matrix polarimetry (MMP) [1,2,3,4,5] approaches are extensively used for the visualization of malformation of biological tissue structure and determination of its functional physiological variations
A laser beam has been separated on two beams
A laser beam has been separated on two beams (“irradiating” and (m × n = 1280 × 960 pixels) of the digital camera 15
Summary
Mueller-matrix polarimetry (MMP) [1,2,3,4,5] approaches are extensively used for the visualization of malformation of biological tissue structure and determination of its functional physiological variations. The main disadvantage of MMP is associated with invasive procedure of preparation of bio-tissue samples that significantly limits its application for biomedicine. The accessible biological liquids, including those obtained from the particular organs, could be used as the main subjects of tissue samples in MMP. The thin film of such biological fluids represents a complex spatially inhomogeneous optically anisotropic structure, which is formed by various types of biochemical and molecular crystalline complexes. Monitoring of the dynamics of crystallization within such thin films provides an opportunity to characterize the internal processes at the macro-level of molecular interaction and to carry out the early diagnosis of various diseases
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