Abstract
We present in this paper the implementation of an innovative three dimensional (3D) microfabrication technology coupled with numerical simulation to enhance the mass transport in 3D cell culture. The core of this microfabrication technology is a high-resolution projection micro stereolithography (PmicroSL) using a spatial light modulator as a dynamic mask which enables a parallel fabrication of highly complex 3D microstructures. In this work, a set of poly (ethylene glycol) microfabricated bioreactors are demonstrated with PmicroSL technology. We observed both experimentally and numerically the regulation of metabolism and the growth of yeast cells by controlling the density of micro-capillaries. Further development of these 3D microfabricated bioreactors is expected to provide artificially constructed tissues for clinical applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.