3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.

Abstract

(Cell Stem Cell 28, 846–862.e1–e8; May 6, 2021)The version of the supplemental information initially published alongside this manuscript was an older, non-final version from earlier in the production process that was mistakenly displayed by the publisher. The non-final version that was not proofread contained a few typos in the figure legends and two incorrect image panels (Figure S3D and Figure S7B). The publisher has replaced the file with the final version that addresses all of these issues and apologizes to the authors for the oversight and the community for any confusion. (Cell Stem Cell 28, 846–862.e1–e8; May 6, 2021) The version of the supplemental information initially published alongside this manuscript was an older, non-final version from earlier in the production process that was mistakenly displayed by the publisher. The non-final version that was not proofread contained a few typos in the figure legends and two incorrect image panels (Figure S3D and Figure S7B). The publisher has replaced the file with the final version that addresses all of these issues and apologizes to the authors for the oversight and the community for any confusion. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degenerationManian et al.Cell Stem CellMarch 29, 2021In BriefWe developed a patient-derived in vitro model of the retinal pigment epithelium (RPE)-choriocapillaris (CC) complex to investigate local and systemic factors underlying age-related macular degeneration (AMD) and similar maculopathies. The model captures hallmarks of RPE-CC morphogenesis and AMD, provides insight into factors that induce dysfunction, and leads to the identification of therapeutic targets. Full-Text PDF Open Archive