Abstract
Modern science has developed well-defined and versatile sets of chemicals to perform many specific tasks, yet the diversity of these reagents is so large that it can be impractical for any one lab to stock everything they might need. At the same time, isssues of stability or limited supply mean these chemicals can be very expensive to purchase from specialist retailers. Here, we address this problem by developing a cartridge -oriented approach to reactionware-based chemical generators which can easily and reliably produce specific reagents from low-cost precursors, requiring minimal expertise and time to operate, potentially in low infrastructure environments. We developed these chemical generators for four specific targets; transition metal catalyst precursor tris(dibenzylideneacetone)dipalladium(0) [Pd2(dba)3], oxidising agent Dess-Martin periodinane (DMP), protein photolinking reagent succinimidyl 4,4’-azipentanoate (NHS-diazirine), and the polyoxometalate cluster {P8W48}. The cartridge synthesis of these materials provides high-quality target compounds in good yields which are suitable for subsequent utilization.
Highlights
1234567890():,; The power of modern chemistry, biology and material science is shown by a range of capabilities such as the ability to design a single-step assembly of complex molecules[1], targeted gene modifications[2], and property-driven materials discovery and manufacturing[3]
The other two examples belong to transition metal catalysis and classical organic synthesis, respectively (Fig. 2)
We have expanded the concept of digitization of organic syntheses, and successfully demonstrated its application to prepare reagents which are of high demand in the modern chemistry and biology labs
Summary
1234567890():,; The power of modern chemistry, biology and material science is shown by a range of capabilities such as the ability to design a single-step assembly of complex molecules[1], targeted gene modifications[2], and property-driven materials discovery and manufacturing[3]. Using simple flow reactors researchers demonstrated synthesis and in situ utilization of reagents that would be unstable under normal conditions such as singlet oxygen[11], diazomethane[12], CF3-radicals[13] and others[14,15,16,17,18] This concept suffers from all classical problems of flow protocols, such as occasional flow path blockage by solids, and, most important, need of highly skilled personnel to operate the devices. The key finding was the workflow to create a digital synthesis blueprint which, once validated, could have been reproduced an infinite number of times in a highly automated manner Such blueprints would in future form an extensive on-line library of published synthetic protocols available to researchers from all over the world. We demonstrate how it is possible to expand this approach to alleviate the problems summarized above, dramatically saving the time and money of expert researchers while providing access to commonly used organic reagents with minimal effort
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