Abstract
Purpose: Anterior cruciate ligament (ACL) rupture is associated with acute joint trauma, chronically altered joint mechanics; and subsequently with an increased risk of incident knee osteoarthritis (OA). It has been reported that the mean femorotibial cartilage thickness increases in young adults after ACL rupture, with the annual rate during the first 2 years (BL→Y2) being similar to that during the subsequent 3 years (Y2→Y5). Previous work has shown that this mean cartilage thickness change does not reflect simultaneous thinning and thickening that occurred in different subregions of the joint, and that simultaneous thinning and thickening actually differed in magnitude between the first and later observation period, independent of treatment.
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